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GLP-1 agonists have the highest regain rate after discontinuation because the appetite suppression effect disappears, leading many people to regain 60-70% of lost weight within a year

Common Degradation Pathways Deamidation of asparagine residues Methionine oxidation Peptide backbone hydrolysis Acyl chain hydrolysis Isomerization reactions Advanced LC-MS methods allow researchers to identify the exact location of degradation events within the peptide sequence

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Most herbal treatments are based on traditional medicine theories, with clinical effectiveness established first, followed by research into their pharmacological mechanisms

10.16352/j.issn.1001-6325.2012.06.010 43 GonggaL.DuojiZ.YangL.LiuL.PasangD